Acetyl-CoA synthetase
Acs
Acetyl-Coenzyme A synthetase (Acs) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). As a crucial enzyme in the Wood-Ljungdahl pathway of carbon fixation, acetyl-CoA synthetase has bifunctional roles, using a nickel-containing bimetallic site to combine carbon monoxide with a methyl group, ultimately converting it into acetyl-CoA. Acetyl-CoA is essential in metabolism and energy generation. The activity of ACS is tightly regulated by complex systems, including carbon flux-mediated gene expression and post-translational regulation via the NAD+/sirtuin-dependent pathway.
Acetyl-CoA synthetase can induce Autophagy, and its mediated histone acetylation plays a significant role in maintaining cellular homeostasis and tumor development[1][2][3].
References:
- [1]. Hegg EL. Unraveling the structure and mechanism of acetyl-coenzyme A synthase. Acc Chem Res. 2004 Oct;37(10):775-83. [Content Brief]
- [2]. Li X, et al. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 1;66(5):684-697.e9. [Content Brief]
- [3]. Starai VJ, et al. Acetyl-coenzyme A synthetase (AMP forming). Cell Mol Life Sci. 2004 Aug;61(16):2020-30. [Content Brief]
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Acetyl-CoA synthetase Related Products (6)
Related Products (6)
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ACSS2-IN-2
0 ImagesACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.
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Acetyl-CoA synthetase
0 ImagesAcetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of thioester bonds between coenzyme A and carboxylic acids, while simultaneously hydrolyzing ATP into AMP and pyrophosphate.
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Isovaleryl-CoA sodium
0 ImagesCat. No.: HY-164093ACAS No.: 6244-91-3Isovaleryl-CoA sodium, a branched-chain acyl CoA, is a succinate:CoA ligase (SCL) inhibitor with an IC50 of 273 μM in rat liver mitochondria.
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Ac-CoA Synthase-IN-2
0 ImagesCat. No.: HY-183249Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections.
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MMV693183
0 ImagesCat. No.: HY-182685CAS No.: 2446681-27-0MMV693183 is an orally active inhibitor of Plasmodium falciparum acetyl-CoA synthetase (AcAS), with an IC50 of 300 nM against Plasmodium falciparum. MMV693183 exhibits potent inhibitory activity against clinical isolates of malaria parasites, including Artemisinin (HY-B0094)-resistant strains. MMV693183 is metabolized in vivo into the active antimetabolite CoA-MMV693183, which exerts effects of killing asexual blood-stage parasites and blocking transmission to Anopheles mosquitoes by binding to and inhibiting the function of acetyl-CoA synthetase, thereby reducing the levels of acetyl-CoA and 4'-phosphopantetheine. In humanized mouse models, MMV693183 shows favorable in vivo efficacy, drug-like properties, and no significant cytotoxicity or off-target activity against human cells. MMV693183 is widely used in malaria-related research as a parasiticide and metabolic disruptor.
